医学
随机对照试验
改变生活方式
内科学
脂肪肝
减肥
胃肠病学
物理疗法
人口
甘油三酯
疾病
肥胖
胆固醇
环境卫生
作者
Vincent Wai–Sun Wong,Randolph C. H. Chan,Grace Lai‐Hung Wong,Bernice Cheung,Winnie C. W. Chu,David W. K. Yeung,Angel Mei–Ling Chim,Jennifer Wing-Yan Lai,Liz Sin Li,Mandy Man-Mei Sea,Francis K.L. Chan,Joseph J.Y. Sung,Jean Woo,Henry Lik‐Yuen Chan
标识
DOI:10.1016/j.jhep.2013.04.013
摘要
Healthy lifestyle is the most important management of non-alcoholic fatty liver disease (NAFLD). This study aimed at assessing the efficacy of a community-based lifestyle modification programme in the remission of NAFLD.This was a parallel group, superiority, randomized controlled trial. 154 adults with NAFLD identified during population screening were randomized to participate in a dietitian-led lifestyle modification programme at 2 community centres or receive usual care for 12 months. The primary outcome was remission of NAFLD at month 12 as evidenced by intrahepatic triglyceride content (IHTG) of less than 5% by proton-magnetic resonance spectroscopy.74 patients in the intervention group and 71 patients in the control group completed all study assessments. In an intention-to-treat analysis of all 154 patients, 64% of the patients in the intervention group and 20% in the control group achieved remission of NAFLD (difference between groups 44%; 95% CI 30-58%; p<0.001). The mean (SD) changes in IHTG from baseline to month 12 were -6.7% (6.1%) in the intervention group and -2.1% (6.4%) in the control group (p<0.001). Body weight decreased by 5.6 (4.4) kg and 0.6 (2.5) kg in the two groups, respectively (p<0.001). While 97% of patients with weight loss of more than 10% had remission of NAFLD, 41% of those with weight loss of 3.0-4.9% could also achieve the primary outcome.The community-based lifestyle modification programme is effective in reducing and normalizing liver fat in NAFLD patients.
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