钒酸盐
内科学
内分泌学
胰岛素
糖尿病
钒
链脲佐菌素
心功能曲线
医学
化学
心力衰竭
生物化学
无机化学
作者
Clayton E. Heyliger,Arun G. Tahiliani,John H. McNeill
出处
期刊:Science
[American Association for the Advancement of Science]
日期:1985-03-22
卷期号:227 (4693): 1474-1477
被引量:711
标识
DOI:10.1126/science.3156405
摘要
The trace element vanadium has an unclear biological function. Vanadate, an oxidized form of vanadium, appears to have an insulin-like action. The effect of vanadate on blood glucose and cardiac performance was assessed in female Wistar rats 6 weeks after they were made diabetic with streptozotocin. When vanadate was administered for a 4-week period to the diabetic rats, their blood glucose was not significantly different from that of nondiabetic controls despite a low serum insulin. In contrast, blood glucose was increased about threefold in the diabetic rats that were not treated with vanadate; these rats also had low insulin levels. Cardiac performance was depressed in the untreated diabetic animals, but the cardiac performance of the vanadate-treated diabetic animals was not significantly different from that of nondiabetic controls. Thus vanadate controlled the high blood glucose and prevented the decline in cardiac performance due to diabetes.
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