斯巴泰因
化学
烷基
对称化
脱质子化
有机化学
胞苷
芳基
立体化学
组合化学
对映选择合成
催化作用
生物化学
离子
受体
烟碱激动剂
作者
Magnus Johansson,Lennart Schwartz,Mohamed Amedjkouh,Nina Kann
标识
DOI:10.1002/ejoc.200400006
摘要
Historically, (−)-sparteine·sec-BuLi has been used to desymmetrize prochiral phosphanes. In this report, derivatives of an alkaloid extracted from the seeds of Laburnum anagyroides have been utilized to mimic (+)-sparteine, which is not readily available. In several cases, the enantioselectivities achieved with the (+)-sparteine surrogates outperformed (−)-sparteine itself in the deprotonation of alkyl-substituted (as well as aryl-substituted) prochiral phosphane derivatives. In addition, use of these surrogates allows a new methodology for a chiral switch in phosphorus chemistry. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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