化学
芳基
酰肼
联氨(抗抑郁剂)
区域选择性
催化作用
铜
分子间力
药物化学
有机化学
组合化学
分子
色谱法
烷基
作者
Martina Wolter,and Artis Klapars,Stephen L. Buchwald
出处
期刊:Organic Letters
[American Chemical Society]
日期:2001-10-19
卷期号:3 (23): 3803-3805
被引量:258
摘要
[reaction--see text] A convenient method for intermolecular N-arylation of hydrazides with substituted aryl iodides in the presence of a copper catalyst and Cs(2)CO(3) is reported. The C-N coupling of N-Boc hydrazine with para- and meta-substituted aryl iodides afforded the N-arylated products A, regioselectively. A reversal in regioselectivity is observed for the arylation of benzoic hydrazide with ortho-substituted aryl iodides, providing the N'-arylated products B.
科研通智能强力驱动
Strongly Powered by AbleSci AI