生物
嗜铬细胞
肠道菌群
胃肠道
微生物学
血清素
细胞生物学
血小板
细菌
运动性
分泌物
生态学
寄主(生物学)
免疫学
生物化学
受体
遗传学
作者
Jessica M. Yano,Kristie Yu,Gregory P. Donaldson,Gauri G. Shastri,Phoebe Ann,Leilei Ma,Cathryn R. Nagler,Rustem F. Ismagilov,Sarkis K. Mazmanian,Elaine Y. Hsiao
出处
期刊:Cell
[Elsevier]
日期:2015-04-01
卷期号:161 (2): 264-276
被引量:2391
标识
DOI:10.1016/j.cell.2015.02.047
摘要
Summary
The gastrointestinal (GI) tract contains much of the body's serotonin (5-hydroxytryptamine, 5-HT), but mechanisms controlling the metabolism of gut-derived 5-HT remain unclear. Here, we demonstrate that the microbiota plays a critical role in regulating host 5-HT. Indigenous spore-forming bacteria (Sp) from the mouse and human microbiota promote 5-HT biosynthesis from colonic enterochromaffin cells (ECs), which supply 5-HT to the mucosa, lumen, and circulating platelets. Importantly, microbiota-dependent effects on gut 5-HT significantly impact host physiology, modulating GI motility and platelet function. We identify select fecal metabolites that are increased by Sp and that elevate 5-HT in chromaffin cell cultures, suggesting direct metabolic signaling of gut microbes to ECs. Furthermore, elevating luminal concentrations of particular microbial metabolites increases colonic and blood 5-HT in germ-free mice. Altogether, these findings demonstrate that Sp are important modulators of host 5-HT and further highlight a key role for host-microbiota interactions in regulating fundamental 5-HT-related biological processes.
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