TNF -induced IP3R1 expression through TNFR1/PC-PLC/PKC and TNFR2 signalling pathways in human mesangial cell

Background. Little information is available regarding the mechanisms involved in cytokine-induced type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) expression in human mesangial cells (HMCs) in the occurrence of hepatorenal syndrome (HRS). Over-expression of IP3R1 would enhance both IP3-binding activity and sensitivity. We hypothesize that it is possible that increased IP3R1, induced by TNFα, would lead to increased IP3 sensitivity in response to a variety of vasoconstrictors, and promote HMC contraction and thus lead to reduced GFP, promoting HRS occurrence and development.