生物
开放式参考框架
同色链霉菌
基因簇
遗传学
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基因
基因座(遗传学)
链霉菌
序列分析
南方斑点
白色链霉菌
核酸序列
肽序列
突变体
细菌
作者
Staffan Bergh,Mathias Uhlén
出处
期刊:Gene
[Elsevier]
日期:1992-08-01
卷期号:117 (1): 131-136
被引量:41
标识
DOI:10.1016/0378-1119(92)90501-f
摘要
A gene cluster homologous to the beta-ketoacyl synthase-encoding gene, actl, was cloned by Southern blot hybridization from Streptomyces curacoi, and a 5469-bp fragment was sequenced. Analysis of the sequence revealed seven open reading frames (ORFs). A striking similarity to the whiE locus (encoding spore pigment synthesis) of Streptomyces coelicolor was found throughout the whole cluster, with conservation of the size and position of the seven ORFs. The structure of these two gene clusters suggests that they have a common origin, although the lower similarity in the noncoding regions suggests that the regulatory regions have diverged through evolution.
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