Ultra–low‐dose radiotherapy for definitive management of ocular adnexal B‐cell lymphoma

ABSTRACT Background The purpose of this study was to report the response to and toxicity of ultra–low‐dose radiotherapy (RT) for B‐cell ocular adnexal lymphoma (OAL). Methods We conducted a retrospective review of patients with indolent B‐cell and mantle cell OAL treated with 4 Gy to the orbit(s) in two 2‐Gy fractions. Disease response was assessed clinically and/or radiographically at 2 to 4‐month intervals after RT. Data collected included rates of overall response, complete response (CR), partial response (PR), and treatment‐related toxic effects. Results Twenty‐two patients (median age, 65 years) had the following histologic subtypes: mucosa‐associated lymphoid tissue (MALT; 14 patients; 64%); follicular lymphoma (5 patients; 23%); mantle cell lymphoma (MCL; 2 patients; 9%); and unclassifiable (1 patient, 4%). The overall response rate was 100%; 19 patients (86%) had a CR and 3 patients (14%) had a PR. The only acute toxic effect was grade 1 dry eye syndrome in 1 patient. Conclusion Ultra–low‐dose RT in patients with OAL is associated with high response rates and minimal toxic effects, and is much shorter in duration and cost. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1095–1100, 2017