癌变
计算生物学
癌症研究
生物
癌症
转化研究
生物信息学
抗癌药物
临床试验
鉴定(生物学)
背景(考古学)
遗传学
生物技术
植物
古生物学
作者
Günter Schneider,Marc Schmidt-Supprian,Roland Rad,Dieter Saur
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2017-03-03
卷期号:17 (4): 239-253
被引量:225
摘要
How can we treat cancer more effectively? Traditionally, tumours from the same anatomical site are treated as one tumour entity. This concept has been challenged by recent breakthroughs in cancer genomics and translational research that have enabled molecular tumour profiling. The identification and validation of cancer drivers that are shared between different tumour types, spurred the new paradigm to target driver pathways across anatomical sites by off-label drug use, or within so-called basket or umbrella trials which are designed to test whether molecular alterations in one tumour entity can be extrapolated to all others. However, recent clinical and preclinical studies suggest that there are tissue- and cell type-specific differences in tumorigenesis and the organization of oncogenic signalling pathways. In this Opinion article, we focus on the molecular, cellular, systemic and environmental determinants of organ-specific tumorigenesis and the mechanisms of context-specific oncogenic signalling outputs. Investigation, recognition and in-depth biological understanding of these differences will be vital for the design of next-generation clinical trials and the implementation of molecularly guided cancer therapies in the future.
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