支架蛋白
锚蛋白重复序列
神经科学
突触
突触后密度
突触后电位
谷氨酸的
自闭症谱系障碍
生物
锚定
自闭症
遗传学
基因
兴奋性突触后电位
谷氨酸受体
抑制性突触后电位
心理学
信号转导
受体
发展心理学
作者
Patrícia Monteiro,Guoping Feng
摘要
Several large-scale genomic studies have supported an association between cases of autism spectrum disorder and mutations in the genes SH3 and multiple ankyrin repeat domains protein 1 (SHANK1), SHANK2 and SHANK3, which encode a family of postsynaptic scaffolding proteins that are present at glutamatergic synapses in the CNS. An evaluation of human genetic data, as well as of in vitro and in vivo animal model data, may allow us to understand how disruption of SHANK scaffolding proteins affects the structure and function of neural circuits and alters behaviour.
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