Uterine Wound Healing: A Complex Process Mediated by Proteins and Peptides

Wound healing is the process by which a complex cascade of biochemical events is responsible of the repair the damage. In vivo, studies in humans and mice suggest that healing and post-healing heterogeneous behavior of the surgically wounded myometrium is both phenotype and genotype dependent. Uterine wound healing process involves many cells: endothelial cells, neutrophils, monocytes/macrophages, lymphocytes, fibroblasts, myometrial cells as well a stem cell population found in the myometrium, myoSP (side population of myometrial cells). Keywords: Pregnancy, cesarean section, myomectomy, labor, delivery, dystocia, transforming growth factor beta, connective tissue growth factor, basic fibroblast growth factor, platelet-derived growth factor, vascular endothelial growth factor, tumor necrosis factor alpha, wound healing.