Modulation of tactile feedback for the execution of dexterous movement

Sensory signals to fine-tune hand movement Skilled hand movements are modulated not only by signals from the motor system but also by sensory feedback. However, little is known about the circuits that regulate these feedback signals and how such regulation might influence movement. Conner et al . combined molecular, electrophysiological, and behavioral approaches in the mouse to identify and characterize inhibitory circuits in the brainstem cuneate nucleus. These circuits can enhance or suppress the transmission of tactile information, thereby affecting behaviors that require dexterous movement of the hand. In addition, there are descending cortical inputs that can inhibit or excite the cuneate nucleus. These findings indicate a new anatomical and functional circuit architecture for the adjustment of tactile feedback. —PRS