医学
白塞病
最后
内科学
粘膜皮肤区
结节性红斑
荟萃分析
优势比
科克伦图书馆
皮肤病科
置信区间
银屑病性关节炎
关节炎
外科
疾病
作者
Yasuhiro Iizuka,Kaoru Takase‐Minegishi,Lisa Hirahara,Yohei Kirino,Yutaro Soejima,Ho Namkoong,Nobuyuki Horita,Ryusuke Yoshimi,Masaki Takeuchi,Mitsuhiro Takeno,Nobuhisa Mizuki,Hitoshi Nakajima
摘要
This study aimed to determine the clinical efficacy of apremilast for oral ulcers (OUs), extra-oral manifestations, and overall disease activity in patients with Behçet's disease (BD).A systematic literature search was performed in PubMed, Embase, Cochrane Library, and Web of Science Core Collection. Studies assessing the treatment effects of apremilast in BD were included. The odds ratios (ORs) of being symptom-free for individual manifestations and mean difference (MD) of Behçet's Disease Current Activity Form (BDCAF) scores were calculated with 95% confidence intervals (CIs) at 12 and 24 weeks using a random-model meta-analysis.Of 259 screened articles, eight were included. After 12 weeks of apremilast treatment the OR of symptom-free was as followings: OUs, 45.76 (95% CI, 13.23-158.31); genital ulcers, 4.56 (95% CI, 2.47-8.44); erythema nodosum, 3.59 (95% CI, 1.11-11.61); pseudofolliculitis, 2.81 (95% CI, 1.29-6.15); and arthritis, 3.55 (95% CI, 1.71-7.40). Furthermore, BDCAF scores at 12 weeks were significantly reduced (MD=-1.38; -1.78 to -0.99). However, the proportion of oral-ulcer-free patients increased at 24 weeks (OR = 14.88; 4.81 to 46.07).The currently accumulated data indicate an improvement in mucocutaneous and articular symptoms by short-term apremilast treatment in patients with BD.
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