特里夫
先天免疫系统
模式识别受体
Toll样受体
获得性免疫系统
信号转导
受体
病原相关分子模式
生物
细胞生物学
免疫系统
免疫学
遗传学
作者
Kiyoshi Takeda,Shizuo Akira
标识
DOI:10.1002/0471142735.im1412s109
摘要
The mammalian Toll-like receptor (TLR) family consists of 13 members, and recognizes specific patterns of microbial components, called pathogen-associated molecular patterns (PAMPs). TLR-dependent recognition of PAMPs leads to activation of the innate immune system, which subsequently leads to activation of antigen-specific adaptive immunity. The TLR-mediated signaling pathways consist of the MyD88-dependent pathway and TRIF-dependent pathway, both of which induce gene expression. This unit discusses mammalian TLRs (TLR1 to 13) that have an essential role in the innate immune recognition of microorganisms. Also discussed are TLR-mediated signaling pathways and antibodies that are available to detect specific TLRs.
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