伊库利珠单抗
阵发性夜间血红蛋白尿
医学
血红蛋白尿
CD59型
溶血
内科学
补体成分5
免疫学
补体系统
抗体
作者
Peter Hillmen,Jeff Szer,Ilene C. Weitz,Alexander Röth,Britta Höchsmann,Jens Panse,Kensuke Usuki,Morag Griffin,Jean‐Jacques Kiladjian,Carlos de Castro,Hisakazu Nishimori,Lisa Tan,Mohamed Hamdani,Pascal Deschatelets,Cedric Francois,F Grossi,Temitayo Ajayi,Antonio M. Risitano,Régis Peffault de la Tour
标识
DOI：10.1056/nejmoa2029073
摘要
Pegcetacoplan was superior to eculizumab in improving hemoglobin and clinical and hematologic outcomes in patients with PNH by providing broad hemolysis control, including control of intravascular and extravascular hemolysis. (Funded by Apellis Pharmaceuticals; PEGASUS ClinicalTrials.gov, NCT03500549.).
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