伊库利珠单抗
阵发性夜间血红蛋白尿
医学
血红蛋白尿
CD59型
溶血
内科学
补体成分5
免疫学
补体系统
抗体
作者
Peter Hillmen,Jeff Szer,Ilene C. Weitz,Alexander Röth,Britta Höchsmann,Jens Panse,Kensuke Usuki,Morag Griffin,Jean‐Jacques Kiladjian,Carlos de Castro,Hisakazu Nishimori,Lisa Tan,Mohamed Hamdani,Pascal Deschatelets,Cedric Francois,F Grossi,Temitayo Ajayi,Antonio M. Risitano,Régis Peffault de Latour
标识
DOI：10.1056/nejmoa2029073
摘要
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease characterized by chronic complement-mediated hemolysis. C5 inhibition controls intravascular hemolysis in untreated PNH but cannot address extravascular hemolysis. Pegcetacoplan, a pegylated peptide targeting proximal complement protein C3, potentially inhibits both intravascular and extravascular hemolysis.
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