Single-Cell Dissection of Schizophrenia Reveals Neurodevelopmental-Synaptic Link and Transcriptional Resilience Associated Cellular State

Schizophrenia is a severe mental illness afflicting young adults just as they approach their full potential, often resulting in a lifetime of severe disability. While many specific genetic and environmental risk factors have been identified, they are universally of low effect size, and their mechanisms of action within the complex cytoarchitecture of the human brain remain poorly understood.