芒柄花素
肌电图
化学
甘草苷元
收缩(语法)
药理学
立体化学
医学
内科学
病理
替代医学
染料木素
大豆黄酮
作者
Sai-Jie Zuo,Donglai Ma,Jing Li,Qiu-Hong Guo,Li Zhou
标识
DOI:10.1080/10286020.2021.2005588
摘要
A series of formononetin derivatives with substituted benzyloxy groups on the 4' position of isoflavone were designed and synthesized. Their vasodilative activities were evaluated by wire myograph system on isolated rat mesenteric arterial ring. The preliminary SAR of target compounds was thus discussed. Compounds 3d and 3e exhibited potent vasodilative activities against the rat mesenteric arterial rings induced contraction with K+. Compounds 3d and 3e also showed antihypertensive effects in SHRs by oral administration.
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