胶质纤维酸性蛋白
单中心
医学
免疫疗法
回顾性队列研究
内科学
免疫学
病理
肿瘤科
免疫组织化学
免疫系统
作者
Jun Xiao,Xin Chen,Ke Shang,Yue Tang,Man Chen,Gang Deng,Chuan Qin,Dai‐Shi Tian
标识
DOI:10.1016/j.jneuroim.2021.577718
摘要
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a recently defined autoimmune meningoencephalomyelitis, associated with GFAP-IgG antibody. A pooled analysis of 324 cases from published literature and a retrospective single-center study were performed, firstly reveals the possibility that patients with myelitic lesions respond better to initial immunotherapy, but are prone to relapse, suggesting a more aggressive and long-term immunosuppressive medication for them. Moreover, our results showed using tacrolimus at maintenance stage exhibited a less tendency to relapse, providing a possibly new choice to future clinical treatments.
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