Molecular mechanism of necroptosis and its effect in IR injury

Necroptosis is a special cell necrosis that is capable of being regulated through particular molecular mechanism.Multiple stimuli could induce necroptosis,complex Ⅰ,complex Ⅱ and RIP1-RIP3 necrosome are critical participants in the necroptosis.Also,necrostatin-1 is a special and potent small-molecular inhibitor of necroptosis.Necroptosis could be an important alternative for cell death in ischemia-reperfusion injury.