病毒学
生物
病毒
大流行
抗原转移
神经氨酸酶
H5N1基因结构
拉伤
抗原漂移
基因组
人口
爆发
甲型流感病毒
基因
遗传学
2019年冠状病毒病(COVID-19)
医学
传染病(医学专业)
疾病
病理
解剖
环境卫生
作者
Jianfeng Xie,Xiaona Shen,Wang MeiAi,Shi-Qin Yang,Meng Huang,Yanhua Zhang,Wen-Qiong Xiu,Yue Weng,Yan Yan-sheng,Kui Zheng
出处
期刊:PubMed
日期:2014-01-01
卷期号:30 (1): 37-43
摘要
This study aims to investigate the characteristics of genomic variation of pandemic A/H1N1/2009 influenza virus isolated in Fujian Province, China. Complete genome sequence analysis was performed on 14 strains of pandemic A/H1N1/2009 influenza virus isolated from Fujian during 2009-2012. All virus strains were typical low-pathogenic influenza viruses, with resistance to amantadine and sensitivity to neuraminidase inhibitors. Eight genome fragments of all strains were closely related to those of A/California/07/2009 (H1N1) vaccine strain, with > or = 98.2% homology. Compared with the vaccine strain, the influenza strains from Fujian had relatively large variation, and variation was identified at 11 amino acid sites of the HA gene of A/Fujiangulou/SWL1155/2012 strain, including 4 sites (H138R, L161I, S185T, and S203T) involved inthree antigen determinants (Ca, Sa, and Sb). In conclusion, the influenza vaccine has a satisfactory protective effect on Fujian population, but the influenza strains from Fujian in 2012 has antigenic drift compared with the vaccine strain, more attention should therefore be paid to the surveillance of mutations of pandemic A/H1N1/2009 influenza virus.
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