Preparation and Physico-chemical Property of Glaucocalyxin A Solid Lipid Nanoparticles

OBJECTIVE:To prepare Glaucocalyxin A solid lipid nanoparticles(SLN) and study its physico-chemical property.METHODS:Glaucocalyxin A solid lipid nanoparticles were prepared by emulsifying solvent-evaporation process and its particle size,morphology,zeta potential,entrapment efficiency and drug release in vitro were studied.RESULTS:The Glaucocalyxin A solid lipid nanoparticles were well-distributed with mean particle size diameter at(190±10.3) nm.The zeta potential was —31.2 mV,and the average entrapment efficiency was(50.45±0.804)%.The drug release profile in vitro was in line with Higuchi linear equation,exhibiting obvious sustained release effects.CONCLUSION:The SLN can be used as new slow-release drug delivery system for Glaucocalyxin A.