放射性配体
正电子发射断层摄影术
神经影像学
放射合成
内化
Pet成像
运输机
临床前影像学
药物开发
神经科学
医学
体内
受体
化学
药理学
生物化学
心理学
生物
药品
基因
生物技术
标识
DOI:10.2174/0929867323666160418114826
摘要
The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and development, but is recognized as being highly challenging at the medicinal chemistry level. This article aims to compile and discuss the main considerations to be taken into account by chemists embarking on programs of radioligand development for PET imaging of brain protein targets. Keywords: PET, radioligand, molecular imaging, positron-emitter, carbon-11, fluorine-18, efflux transporter, blood-brain barrier.
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