Organophosphate compounds have been widely used in the agricultural production.Acute organophosphate poisoning leads to the cholinesterase inhibition,endotoxin intrusion and cytokine secretion increase.Chronic organophosphate poisoning leads to the paraoxonase inhibition,peroxidation and cytokine increase.In clinic,organophosphate poisoning would lead to the functional injury of many organs and many systems in the organism.The effects of organophosphate compounds on the organism were sum up.