Effects of sodium butyrate on cell growth inhibition and apoptosis in the human cell of gastric carcinoma

Objective:To investigate the effects of sodium butyrate on cell growth inhibition and apoptosis in cell of gastric carcinoma and to explore its mechanism.Methods:MTT assay was used to observe the inhibitory complexion of sodium butyrate on SGC-7901 cells at various concentrations.The expression of apoptosis-related gene protein p21WAF1 was detected by immunohistochemical staining.Results:SGC-7901 cells growth was significantly inhibited by sodium butyrate and the inhibitory affect was in time and dose-dependent manner;The level of p21WAF1 was higher in the sodium butyrate treated cell than the cell without treatment.Conclusion:Sodium butyrate can inhibit the cell growth and induce apoptosis in SGC-7901.Therefore,to explore the mechanism of sodium butyrate in the human cell of gastric carcinoma can provide a new mentality to the gastric carcinoma chemotherapy.