Silver‐Mediated Oxidative Fluorotrifluoromethylation of Unactivated Alkenes

Abstract An efficient regioselective fluorotrifluoromethylation of unactivated alkenes has been developed. The reaction of alkenes with (trifluoromethyl)trimethylsilane (TMSCF 3 ) and Selectfluor in the presence of silver trifluoromethanesulfonate (AgOTf), cesium fluoride (CsF), and iodobenzene diacetate [PhI(OAc) 2 ] in N , N ‐dimethylformamide (DMF) at −20 °C gave the corresponding fluorotrifluoromethylated products in moderate to good yields. The silver salt turns out to be crucial for this transformation. magnified image