医学
淋巴结切除术
淋巴结
解剖(医学)
外科
腹腔镜检查
宫颈癌
淋巴
体质指数
癌症
内科学
精神科
作者
Anna Jacob,Andrea Plaikner,Achim Schneider,Giovanni Favero,Roberto Tozzi,Peter Mallmann,Christian Domröse,Peter Martus,Simone Marnitz,Jana Barinoff,Christhardt Köhler
出处
期刊:International Journal of Gynecological Cancer
[BMJ]
日期:2020-10-09
标识
DOI:10.1136/ijgc-2020-001677
摘要
Objective Lymphadenectomy is an integral part of surgical staging and treatment for patients with gynecologic malignancies. Since its introduction, laparoscopic lymphadenectomy has proved feasible, safe, and oncologically adequate compared with open surgery while morbidity is lower and hospital stay considerably shorter. The aim of this study was to examine if surgical outcomes may be improved after the initial learning curve is complete. Methods An analysis of 2535 laparoscopic pelvic and/or para-aortic lymphadenectomies was performed between July 1994 and March 2018 by one team of gynecologic oncology surgeons but with the consistent supervision of a consultant surgeon. Data were collected prospectively evaluating operative time, intra-operative and post-operative complications, number of lymph nodes, and body mass index (BMI). Previously published data of 650 patients treated after introduction of the method (period 1, 1994–2003) were compared with the latter 524 patients (period 2, 2014–2018). Results The median age of the 2535 patients was 43 years (IQR 34–57). The most common indication for pelvic and/or para-aortic lymphadenectomy was cervical cancer (n=1893). Operative time for para-aortic lymph node dissection was shorter in period 2 (68 vs 100 min, p<0.001). The number of harvested lymph nodes was increased for pelvic (19.2 (range 2–52) vs 21.9 (range 4–87)) and para-aortic lymphadenectomy (10.8 (range 1–52) vs 14.4 (range 4–64)), p<0.001. BMI did not have a significant influence on node count or operative time, with BMI ranging from 14.6 to 54.1 kg/m 2 . In contrast to period 1 (n=18, 2.9%), there were no intra-operative complications in period 2 (n=0, 0.0%, p<0.001) whereas post-operative complications were similar (n=35 (5.8%) in period 1; n=38 (7.6%) in period 2; p=0.32). Conclusion In this large cohort of patients who underwent laparoscopic transperitoneal lymphadenectomy, lymph node count and peri-operative complications improved after the initial learning curve.
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