幽门螺杆菌
混淆
医学
逻辑回归
内科学
胃肠病学
维生素D与神经学
疾病
横断面研究
病例对照研究
免疫学
病理
作者
Elie Salem-Sokhn,Ali Salami,Mirna Fawaz,Ali H. Eid,Said El Shamieh
出处
期刊:Current Aging Science
[Bentham Science]
日期:2021-05-06
卷期号:14 (1): 26-31
被引量:5
标识
DOI:10.2174/1874609813666200925104248
摘要
Hypertension is a multifactorial disease where numerous constitutive, genetic, and environmental factors interplay. Among the constitutive factors, age is a major determent continuously reported to be associated with a significant increase in the prevalence of hypertension. In addition to age, Helicobacter pylori (H. pylori) infection was also shown to be associated. On the other hand, Vitamin D (Vit D) plays an important role in the development of hypertension. In the current study, it was investigated whether H. pylori interacts with Vit D levels to influence hypertension. ; Methods: This cross-sectional study was conducted on seven hundred and eighty-two "a priori" healthy individuals equally divided according to hypertension status. To study the association between Vit D, H. pylori, and hypertension, a multivariate logistic regression model was used while correcting for different confounding factors. Power analysis was also performed. ; Results: Approximately half of the participants were hypertensive and had Vit D insufficiency and they were also matched for age. Using a multiple logistic regression model, the results showed an inversely proportionate association between H. pylori infection and the risk of hypertension (OR=0.38, P<0.001). On the other hand, a proportionate association between Vit D deficiency and hypertension was observed (OR=2.76, P=0.004). Furthermore, Vit D and H. pylori status interacted to affect the risk of hypertension (OR=0.97, P=0.004). Stratification, according to Vit D status, showed that 59.1% of Vit D deficient participants were infected with H. pylori organisms (P<0.001). When taking hypertension, Vit D, and H. pylori statuses into account, it was found that the prevalence of hypertension was doubled when the participants were negative for H. pylori infection but had Vit D deficiency (P<0.001). ; Conclusion: H. pylori infection and Vit D deficiency could predict hypertension. The odds of hypertension development were double when the participants were negative for H. pylori infection and had vitamin D deficiency.
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