化学
水溶液
水介质
有机化学
组分(热力学)
组合化学
芳基
作者
Jin-Quan Chen,Jia Guo,Zhi-Bing Dong
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2020-07-01
卷期号:52 (13): 1927-1933
被引量:1
标识
DOI:10.1055/s-0039-1690854
摘要
A highly efficient three-component protocol for the synthesis of the 2-alkylthiobenzoazoles is described. Tetramethylthiuram disulfide (TMTD) cyclized with o-aminothiophenols, generating the intermediate 2-mercaptobenzothiazoles, and the successive C–S coupling with halogenated alkanes afforded a series of 2-alkyl-substituted thiobenzothiazoles smoothly in a one-pot process. This procedure could also be utilized for the preparation of 2-alkyl-substituted thiobenzoxazoles and 2-alkyl-substituted thiobenzimidazoles. Inexpensive and easily available starting materials, metal catalyst-free, broad substrate scope, and water as solvent are the features of this protocol.
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