表观遗传学
癌症干细胞
癌症
CD44细胞
表观遗传疗法
组蛋白脱乙酰基酶
生物
染色质
癌症研究
癌症表观遗传学
计算生物学
生物信息学
作者
Audrey Vincent,Aïcha Ouelkdite-Oumouchal,Mouloud Souidi,Julie Leclerc,Bernadette Neve,Isabelle Van Seuningen
出处
期刊:World Journal of Stem Cells
[Baishideng Publishing Group Co (World Journal of Stem Cells)]
日期:2019-11-26
卷期号:11 (11): 920-936
被引量:13
标识
DOI:10.4252/wjsc.v11.i11.920
摘要
The recent discovery of cancer cell plasticity, i.e. their ability to reprogram into cancer stem cells (CSCs) either naturally or under chemotherapy and/or radiotherapy, has changed, once again, the way we consider cancer treatment. If cancer stemness is a reversible epigenetic state rather than a genetic identity, opportunities will arise for therapeutic strategies that remodel epigenetic landscapes of CSCs. However, the systematic use of DNA methyltransferase and histone deacetylase inhibitors, alone or in combination, in advanced solid tumors including colorectal cancers, regardless of their molecular subtypes, does not seem to be the best strategy. In this review, we first summarize the knowledge researchers have gathered on the epigenetic signatures of CSCs with the difficulty of isolating rare populations of cells. We raise questions about the relevant use of currently available epigenetic inhibitors (epidrugs) while the expression of numerous cancer stem cell markers are often repressed by epigenetic mechanisms. These markers include the three cluster of differentiation CD133, CD44 and CD166 that have been extensively used for the isolation of colon CSCs.and . Finally, we describe current treatment strategies using epidrugs, and we hypothesize that, using correlation tools comparing associations of relevant CSC markers with chromatin modifier expression, we could identify better candidates for epienzyme targeting.
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