生发中心
免疫球蛋白E
等离子体电池
抗体
免疫学
免疫球蛋白类转换
生物
B细胞
记忆B细胞
细胞生物学
作者
Jiahui He,Sriram Narayanan,Sharrada Subramaniam,Wen Qi Ho,Juan J. Lafaille,Maria A. Curotto de Lafaille
出处
期刊:Current Topics in Microbiology and Immunology
日期:2015-01-01
卷期号:: 1-19
被引量:38
标识
DOI:10.1007/978-3-319-13725-4_1
摘要
The generation of long-lived plasma cells and memory B cells producing high-affinity antibodies depends on the maturation of B cell responses in germinal centers. These processes are essential for long-lasting antibody-mediated protection against infections. IgE antibodiesIgE antibodies are important for defense against parasites and toxins and can also mediate anti-tumor immunity. However, high-affinity IgE is also the main culprit responsible for the manifestations of allergic disease, including life-threatening anaphylaxisAnaphylaxis . Thus, generation of high-affinity IgE must be tightly regulated. Recent studies of IgE B cell biology have unveiled two mechanisms that limit high-affinity IgE memory responses: First, B cells that have recently switched to IgE production are programmed to rapidly differentiate into plasma cells,Plasma cells and second, IgE germinal centerGerminal center cells are transient and highly apoptotic. Opposing these processes, we now know that germinal center-derived IgG B cells can switch to IgE production, effectively becoming IgE-producing plasma cells. In this chapter, we will discuss the unique molecular and cellular pathways involved in the generation of IgE antibodies.
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