AIM: The aim of this study is to present the early results and to discuss the new method of treatment of ano-rectal fistula with SURGISIS AFP ANAL FISTULA PLUG. MATERIAL AND METHODS: Three patients with ano-rectal fistula have been treated in the Department of General Surgery with Coloproctology, using Surgisist AFP anal fistula Plug. Two were with transsphincter and one with extrasphincter ano-rectal fistula. This method of SURGISIS AFP ANAL FISTULA PLUG treatment is presented in details. RESULTS: All patients are with closed fistulas after period of 4, 8 and 12 weeks of follow up. The author emphasized, that with the presented way of treatment the period of hospitalization is shorter, postoperative pain and period of healing are reduced. There are a lot of advantages using this method, compared with the traditional surgical methods. CONCLUSION: The presented material is insignificant, but it helps to initiate a new noninvasive method of treatment of ano-rectal fistula. Surgisist AFP anal fistula Plug method is a safe and successful. It preserves the anal anatomy and function. The data results, which are presented should be reproduced in a wider future study.