Toxicity of three Sophora flavescens Ait alkaloids to mice.

The toxicity of three Sophora flavescens Ait alkaloids(Oxymatrine,sophoridine,matrine) to mice were systematically researched in this paper.Results are as below:the toxicity of Sophora flavescens Ait alkaloids which acted on mice were increased after mixture.In matrine and sophoridine group,c.f value was 59.1.In oxymatrine and matrine group,c.f value was 37.3,showing the synergy effects;In oxymatrine and sophoridine group,c.f value was 13.6 which indicated that had additive effect.The results of blood routine determination showed that WLT,PLT and GR were higher than those of control(P0.01).Examining the blood biochemical indicators,in the oxymatrine and sophoridine group,BUN and Cr of samples were all higher(P0.01) than those of control,In the matrine group,the quality of ALT and AST were higher than those of control(P0.01).The coefficients of kidney,heart,liver were significant higher than those of control from the statistical results of organ coefficients(P0.01,P0.05,P0.05).According to the above results,the target organs on which Sophora flavescens Ait alkaloids acted were kidney and liver.