溶致性
中间相
癸酸
小角X射线散射
溶致液晶
纳米颗粒
小旋翼机
液晶
磷脂
化学工程
层状相
相(物质)
六角相
脂质双层
层状结构
化学
胶束
材料科学
有机化学
结晶学
膜
纳米技术
共聚物
散射
脂肪酸
液晶
聚合物
工程类
水溶液
物理
光学
生物化学
光电子学
月桂酸
作者
Jiali Zhai,Nhiem Tran,Sampa Sarkar,Celesta Fong,Xavier Mulet,Calum J. Drummond
出处
期刊:Langmuir
[American Chemical Society]
日期:2017-02-27
卷期号:33 (10): 2571-2580
被引量:34
标识
DOI:10.1021/acs.langmuir.6b04045
摘要
We report here the lyotropic liquid crystalline phase behavior of two lipid nanoparticulate systems containing mixtures of monoolein, capric acid, and saturated diacyl phosphatidylcholines dispersed by the Pluronic F127 block copolymer. Synchrotron small-angle X-ray scattering (SAXS) was used to screen the phase behavior of a library of lipid nanoparticles in a high-throughput manner. It was found that adding capric acid and phosphatidylcholines had opposing effects on the spontaneous membrane curvature of the monoolein lipid layer and hence the internal mesophase of the final nanoparticles. By varying the relative concentration of the three lipid components, we were able to establish a library of nanoparticles with a wide range of mesophases including at least the inverse bicontinuous primitive and double diamond cubic phases, the inverse hexagonal phase, the fluid lamellar phase, and possibly other phases. Furthermore, the in vitro cytotoxicity assay showed that the endogenous phospholipid-containing nanoparticles were less toxic to cultured cell lines compared to monoolein-based counterparts, improving the potential of the nonlamellar lipid nanoparticles for biomedical applications.
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