细胞力学
原子力显微镜
纳米技术
生物医学
分子力学
连续介质力学
力谱学
细胞
机械
材料科学
化学
物理
分子动力学
生物
生物信息学
生物化学
计算化学
细胞骨架
作者
Mi Li,Dan Dang,Lianqing Liu,Ning Xi,Yuechao Wang
出处
期刊:IEEE Transactions on Nanobioscience
[Institute of Electrical and Electronics Engineers]
日期:2017-09-01
卷期号:16 (6): 523-540
被引量:89
标识
DOI:10.1109/tnb.2017.2714462
摘要
Cell mechanics is a novel label-free biomarker for indicating cell states and pathological changes. The advent of atomic force microscopy (AFM) provides a powerful tool for quantifying the mechanical properties of single living cells in aqueous conditions. The wide use of AFM in characterizing cell mechanics in the past two decades has yielded remarkable novel insights in understanding the development and progression of certain diseases, such as cancer, showing the huge potential of cell mechanics for practical applications in the field of biomedicine. In this paper, we reviewed the utilization of AFM to characterize cell mechanics. First, the principle and method of AFM single-cell mechanical analysis was presented, along with the mechanical responses of cells to representative external stimuli measured by AFM. Next, the unique changes of cell mechanics in two types of physiological processes (stem cell differentiation, cancer metastasis) revealed by AFM were summarized. After that, the molecular mechanisms guiding cell mechanics were analyzed. Finally the challenges and future directions were discussed.
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