医学
内科学
危险系数
比例危险模型
逻辑回归
心脏病学
冠状动脉疾病
单核细胞
白细胞
优势比
前瞻性队列研究
风险因素
置信区间
作者
Sung Hee Choi,Jung Hee Kim,Soo Lim,Jae Young Lim,Ki Woong Kim,Kyong Soo Park,Hak Chul Jang
出处
期刊:Age and Ageing
[Oxford University Press]
日期:2016-12-08
卷期号:46 (3): 433-438
被引量:21
标识
DOI:10.1093/ageing/afw226
摘要
white blood cells (WBCs) have been known to mediate the inflammatory process, which may be a pivotal mechanism for atherosclerosis and cardiovascular mortality.we investigated which WBC subtypes increased cardiovascular mortality and explored its connection to coronary artery diseases in a prospective study among older Koreans.this study was conducted from 2005 to 2011 as a part of the Korean Longitudinal Study on Health and Aging and included 439 men and 561 women over 65-year old.the primary endpoints were all-cause and cardiovascular mortality.in the cox proportional hazard models, subjects in the higher tertiles of monocyte count were at a higher risk for cardiovascular mortality even in the fully adjusted model (2nd tertile hazard ratio = 2.51; 3rd tertile = 2.81). However, the total WBC, neutrophil and lymphocyte counts did not affect cardiovascular mortality. Logistic regression models revealed that subjects in the 3rd tertile of monocyte count had an increased risk for any coronary artery plaque, vulnerable plaque and calcified plaque (odds ratio = 1.80, 2.68, 1.59, respectively) but not for significant stenosis. Other WBC subtypes were not related to coronary artery diseases.the results showed that a high monocyte count is a risk factor for cardiovascular mortality as well as coronary artery plaque formation.
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