下调和上调
基因敲除
癌症研究
癌基因
生物
Wnt信号通路
肾细胞癌
上皮-间质转换
细胞
细胞生长
肿瘤进展
细胞凋亡
病理
信号转导
癌症
细胞周期
细胞生物学
医学
基因
生物化学
遗传学
作者
Heng Chen,Xiuwu Pan,Liang Zhang,Xingang Cui,Jianqing Ye
摘要
Renal cell carcinoma (RCC) is one of the most common urological cancers in adults. Forkhead box k1 (FOXK1) is a transcription factor involved in the progression of various malignant tumors. In this study, we aimed to investigate the expression and roles of FOXK1 in RCC development. Our findings revealed increased expression of FOXK1 in RCC tumor tissues and cell lines compared with normal controls. Functional assays demonstrated that knockdown of FOXK1 significantly inhibited proliferation, migration, invasion, and promoted apoptosis in RCC cells. Furthermore, FOXK1 knockdown suppressed epithelial-mesenchymal transition and Wnt signaling in RCC cells. Additionally, we observed a correlation between FOXK1 upregulation and tumor associated macrophages infiltration in RCC. These results suggest that FOXK1 acts as an oncogene in RCC and may serve as a potential therapeutic target for RCC treatment.
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