癌变
癌症
生物
治疗方法
癌细胞
生物信息学
癌症研究
计算生物学
医学
疾病
病理
遗传学
作者
Ying Cai,Zhen Wang,Sifan Guo,Chunsheng Lin,Hong Ye,Qiang Yang,Yan Wang,Xiaodan Yu,Xiaozhou He,Wei Sun,Shi Qiu,Yu Guo,Suo-Qin Tang,Yiqiang Xie,Aihua Zhang
标识
DOI:10.1016/j.tem.2023.08.018
摘要
Metabolic abnormalities are a hallmark of cancer cells and are essential to tumor progression. Oncometabolites have pleiotropic effects on cancer biology and affect a plethora of processes, from oncogenesis and metabolism to therapeutic resistance. Targeting oncometabolites, therefore, could offer promising therapeutic avenues against tumor growth and resistance to treatments. Recent advances in characterizing the metabolic profiles of cancer cells are shedding light on the underlying mechanisms and associated metabolic networks. This review summarizes the diverse detection methods, molecular mechanisms, and therapeutic targets of oncometabolites, which may lead to targeting oncometabolism for cancer therapy.
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