医学
心房颤动
冲程(发动机)
左心耳阻塞
内科学
心脏病学
心包积液
围手术期
闭塞
栓塞
临床终点
心耳
血栓栓塞性中风
外科
随机对照试验
窦性心律
华法林
机械工程
工程类
作者
Abdul Basit Bangash,Yuechun Li,Weijian Huang,Jingquan Zhong,Hongmei Zheng,Dayong Zhang,Anmin Zeng,Rui Wang,Wen-Biao Zhao,Maojing Wang,Yu Zhang,Yu Lu,Qiang Liu,Jingquan Zhong,Chenyang Jiang,Jinhua Zhang
摘要
Abstract Background Patients with non‐valvular atrial fibrillation (NVAF) and previous stroke have a significantly higher risk of stroke recurrence. This study aimed to examine the safety and efficacy of the LAmbre left atrial appendage occlusion device in NVAF patients with a history of stroke. Methods We examined 103 consecutive NVAF patients in 11 Chinese medical centers who had a history of stroke or transient ischemic attacks (TIA) and underwent placement of the LAmbre device. Follow‐up was conducted 1, 3, 6, and 12 months after the procedure. The primary endpoints were the incidence of new ischemic or hemorrhagic stroke, TIA, systemic embolism, or cardiac death. Secondary endpoints were serious perioperative or device‐related complications and cerebral, gastrointestinal, or other bleeding events requiring transfusion of at least 2 units of packed red blood cells. Results Mean patient age was 67.63 ± 7.14 years; mean CHA2DS2‐VASc score was 4.72 ± 1.18 and mean HAS‐BLED score was 1.90 ± 1.00. LAmbre device placement was successful in 101 patients (98.05%). Mean follow‐up was 12.2 months. Five patients (4.95%) developed a new pericardial effusion after the procedure; none required treatment. Eighty‐six patients (85.15%) exhibited no peri‐device leak (PDL). However, 13 (12.8%) had a small (0–3 mm) PDL and two (2.3%) had a moderate PDL (3–5 mm). One recurrent stroke occurred during follow‐up (1.1%). No other complications occurred. Conclusions This multicenter study shows the safety and efficacy of LAmbre left atrial appendage occlusion for NVAF patients with a history of stroke or TIA.
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