肠易激综合征
炎症
免疫系统
功能性胃肠病
疾病
肠-脑轴
免疫学
病因学
免疫
炎症性肠病
医学
胃肠病学
内科学
作者
Yang Yuan,X. Wang,Shengping Huang,Hao Wang,Guo-Ming Shen
标识
DOI:10.1080/19490976.2023.2263209
摘要
Irritable bowel syndrome is a common functional gastrointestinal disorder, and it has been shown that the etiology of irritable bowel syndrome is a multifactorial complex of neurological, inflammatory, and immunological changes. There is growing evidence of low-grade chronic inflammation in irritable bowel patients. The peripheral action response of their intestinal immune factors is integrated into the central nervous system, while the microbiota interacts with the brain-gut axis contributing to the development of low-grade chronic inflammation. The objective of this review is to present a discussion about the impact of immune-brain-gut axis-inflammation interactions on irritable bowel syndrome, its clinical relevance in the course of irritable bowel syndrome disease, and possible therapeutic modalities.
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