医学
内科学
经皮冠状动脉介入治疗
危险系数
心脏病学
传统PCI
2型糖尿病
心肌梗塞
糖尿病
比例危险模型
置信区间
临床终点
内分泌学
随机对照试验
作者
Xiao Long Lin,Qiu Yu Li,Dong Zhao,Jing Hua Liu,Qingyu Fan
出处
期刊:Journal of Investigative Medicine
[BMJ]
日期:2023-02-02
卷期号:71 (5): 471-481
被引量:4
标识
DOI:10.1177/10815589231152823
摘要
Triglyceride-glucose index (TyG index) is a reliable surrogate marker of insulin resistance, associated with morbidity and prognosis of cardiovascular disease. However, its predictive value for cardiovascular events in patients with type 2 diabetes mellitus (T2DM) and chronic total occlusion (CTO) after percutaneous coronary intervention (PCI) has not been studied. Here, we retrospectively enrolled 681 patients with T2DM and CTO after PCI. Patients were divided into two groups based on a median TyG index of 9.02. The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. The primary observational end point was the composite of overall death, nonfatal myocardial infarction, and unplanned revascularization. The Multivariate Cox hazards regression analysis showed that the TyG index was significantly correlated with the primary end point (hazard ratio = 1.699, 95% confidence interval 1.254–2.303, p = 0.001). The addition of TyG to a baseline risk model had an incremental effect on the predictive value for the primary end point (area under the curve: TyG index vs baseline model, 0.693 vs 0.663, comparison p = 0.040; integrated discrimination improvement = 0.049, p = 0.020). The TyG index might be a predictor of adverse cardiovascular events. Moreover, adding the TyG index into a baseline risk model had a cumulative effect on the predictive potential for the primary end point.
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