乳腺癌
癌症研究
生物标志物
医学
癌症
突变
肿瘤科
生物
内科学
生物标志物发现
基因
生物信息学
作者
Francesca Bonechi,Marina Bacci,Nicla Lorito,Alfredo Smiriglia,Angela Subbiani,Edoardo Pagliantini,Giuseppina Comito,Giulia Gangarossa,Assia Duatti,Rania El Botty,Laura Sourd,Elisabetta Romano,Gabriele Tani,Ilenia Segatto,Barbara Belletti,Icro Meattini,Lorenzo Livi,Bruna Cerbelli,Andrea Botticelli,Marco Fiorillo
出处
期刊：Cancer Research
[American Association for Cancer Research]
日期：2025-11-07
卷期号：86 (3): 679-692
标识
DOI：10.1158/0008-5472.can-25-1339
摘要
ESR1 mutations in breast cancer induce metabolic changes that trigger ferroptosis sensitivity, enabling ferroptosis inducers to enhance selective ER degraders' efficacy and positioning ACSL4 as a biomarker for guiding therapy in endocrine-resistant disease.
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