Combined association of triglyceride-glucose index and the atherogenic index of plasma with the incidence of cardiovascular diseases among middle-aged and older population

Both baseline and longitudinal changes of TyG-AIP were independently associated with the risk of developing CVDs, especially stroke, in middle-aged and older Chinese adults. Repeated assessment of TyG-AIP captured cardiometabolic deterioration over time and improved identification of individuals at elevated cardiovascular risk. Incorporating long-term monitoring of TyG-AIP into routine health evaluations may enhance population-level CVDs risk prediction and support more effective prevention strategies.