Copper-catalyzed synthesis of glycosyl carboxamides from glycosyl carboxylic acids and isocyanates

We have developed a copper-catalyzed protocol for synthesizing glycosyl carboxamides from glycosyl carboxylic acids and isocyanates for the first time. This method features a broad substrate scope, mild conditions and high atom economy. Mechanistic studies suggest that this reaction proceeds through a Mumm-type rearrangement.