传出细胞增多
机械生物学
细胞生物学
癌细胞
细胞凋亡
材料科学
涂层
癌症
炎症
程序性细胞死亡
纳米技术
癌症研究
生物物理学
化学
医学
生物
免疫学
巨噬细胞
内科学
体外
生物化学
作者
Louis Van der Meeren,Yulia A. Efimova,Robin Demuynck,Bogdan Parakhonskiy,Dmitri V. Krysko,André G. Skirtach
标识
DOI:10.1002/adhm.202301025
摘要
The importance of the clearance of dead cells is shown to have a regulatory role for normal tissue homeostasis and for the modulation of immune responses. However, how mechanobiological properties of dead cells affect efferocytosis remains largely unknown. Here, it is reported that the Young's modulus of cancer cells undergoing ferroptosis is reduced. To modulate their Young's modulus a layer-by-layer (LbL) nanocoating is developed. Scanning electron and fluorescence microscopy confirm coating efficiency of ferroptotic cells while atomic force microscopy reveals encapsulation of the dead cells increases their Young's modulus dependent on the number of applied LbL layers which increases their efferocytosis by primary macrophages. This work demonstrates the crucial role of mechanobiology of dead cells in regulating their efferocytosis by macrophages which can be exploited for the development of novel therapeutic strategies for diseases where modulation of efferocytosis can be potentially beneficial and for the design of drug delivery systems for cancer therapy.
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