Psychiatric disorders and Type 2 diabetes mellitus: A bidirectional Mendelian randomization

孟德尔随机化 重性抑郁障碍 注意缺陷多动障碍 惊恐障碍 精神科 医学 广泛性焦虑症 双相情感障碍 2型糖尿病 内科学 体质指数 糖尿病 焦虑 心情 遗传学 内分泌学 生物 基因型 基因 遗传变异
作者
Haoran Tao,Shujin Fan,Tianxin Zhu,Lili You,Dinghao Zheng,Li Yan,Meng Ren
出处
期刊:European Journal of Clinical Investigation [Wiley]
卷期号:53 (3) 被引量:31
标识
DOI:10.1111/eci.13893
摘要

Extensive observational evidence put forward the association between psychiatric disorders and type 2 diabetes mellitus (T2DM). However, causal relationships between these two diseases required further research. Thus, we evaluated the bidirection casual effect between five psychiatric disorders and T2DM using two-sample mendelian randomization (MR).By selecting single nucleotide polymorphisms associated with T2DM and five psychiatric disorders (attention-deficit hyperactivity disorder (ADHD), major depressive disorder (MDD), schizophrenia, anxiety disorder and panic disorder), a bidirectional two-sample MR was applied to evaluate causality between these diseases. The inverse-variance weighted (IVW) method was used as the primary analysing approach for estimating possible causal effects. MR-Egger and weighted median were also conducted to verify the results. The funnel plot, Cochran's Q test and MR-Egger intercept test were used for sensitivity analyses. In addition, potential mediators were investigated by risk factor analyses.Genetic susceptibilities of ADHD and MDD would increase the risk of T2DM (ADHD: OR = 1.14, 95%CI 1.08-1.20; p=5.7×10-6 ; MDD: OR = 1.22, 95%CI 1.09-1.36; p=0.0004 ). In addition, genetic predisposition to T2DM was also associated with ADHD (OR = 1.09, 95%CI 1.04-1.14; p = 0.0004). Several risk factors of T2DM were implicated in the above causal associations, including smoking, high body mass index, waist-to-hip ratio and elevated serum triglycerides.Our studies indicated a causal effect of ADHD and MDD on increasing the risk of T2DM, which was potentially mediated by smoking and obesity-related phenotypes. Meanwhile, we found a causal effect of T2DM on ADHD. Thus, prevention strategies for T2DM should also include mental health and vice versa.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
zhang完成签到 ,获得积分10
5秒前
李爱国应助明理的凌旋采纳,获得10
5秒前
今后应助科研通管家采纳,获得20
6秒前
NexusExplorer应助科研通管家采纳,获得10
6秒前
SciGPT应助科研通管家采纳,获得10
6秒前
6秒前
8秒前
江湖笑发布了新的文献求助10
8秒前
8秒前
Jasper应助exosome采纳,获得10
10秒前
13秒前
13秒前
13秒前
jiulin完成签到,获得积分20
15秒前
15秒前
江湖笑完成签到,获得积分10
16秒前
cjn发布了新的文献求助10
18秒前
20秒前
21秒前
小云发布了新的文献求助10
22秒前
研友_VZG7GZ应助呼吸小研狗采纳,获得10
24秒前
25秒前
26秒前
啦啦啦发布了新的文献求助10
26秒前
CHO完成签到,获得积分10
27秒前
28秒前
30秒前
30秒前
白瓜完成签到 ,获得积分10
30秒前
squeak发布了新的文献求助10
32秒前
从容山兰发布了新的文献求助10
32秒前
34秒前
36秒前
淼淼1完成签到,获得积分10
38秒前
40秒前
明理的凌旋完成签到,获得积分20
40秒前
41秒前
43秒前
chcmuer发布了新的文献求助10
44秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
Mixing the elements of mass customisation 300
the MD Anderson Surgical Oncology Manual, Seventh Edition 300
Nucleophilic substitution in azasydnone-modified dinitroanisoles 300
Platinum-group elements : mineralogy, geology, recovery 260
Geopora asiatica sp. nov. from Pakistan 230
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3780560
求助须知:如何正确求助?哪些是违规求助? 3326076
关于积分的说明 10225366
捐赠科研通 3041143
什么是DOI,文献DOI怎么找? 1669215
邀请新用户注册赠送积分活动 799024
科研通“疑难数据库(出版商)”最低求助积分说明 758669