Altered blood–brain barrier permeability is associated with abnormal distant connectivity and regional homogeneity in covert hepatic encephalopathy—A cross-sectional study

There was a strong association between disrupted blood-brain barrier integrity and attenuated functional connectivity, with reductions in functional connectivity within the DMN and Frontoparietal Network (FPN), circuits closely linked to executive control. This attenuation was evident both in local regional and in distant connectivity within these networks.