后悔
甲状腺切除术
医学
甲状腺全切除术
队列
队列研究
甲状腺
多中心研究
甲状腺乳突癌
内科学
甲状腺癌
数学
统计
随机对照试验
作者
Genpeng Li,Ruicen Li,Jinjing Zhong,Wenjie Chen,Jin-Hao Shuai,Meizhu Chen,Feng Deng,Tao Wei,Huairong Tang,Zhihui Li,Jianyong Lei
标识
DOI:10.1038/s41467-025-57627-7
摘要
The level of thyroidectomy-related regret in patients with clinically low-risk papillary thyroid microcarcinoma (PTMC) and the determinants of decision regret are largely unknown. Here, we show that 319 (24.2%) of those who undergo thyroidectomy and 4 (3.4%) who undergo active surveillance (AS) express heightened regret based on validated decision regret scale (DRS) scores in the first online survey (P < 0.001). Multivariable analysis and the second online survey for patients with heightened regret confirm that postoperative lower thyroid cancer-specific quality of life (QoL) (scar and psychology) (75.5%) is the most common factor for heightened regret of thyroidectomy, followed by preoperative understanding of disease [not at all] (15.0%), presentation of complications (3.8%) and other factors (5.7%). These results highlight that more caution should be exercised when low-risk PTMC patients are scheduled for thyroidectomy. Information about the various treatments for clinically low-risk PTMC, the risk of thyroidectomy and postoperative QoL should be fully communicated during initial counseling. Thyroidectomy is frequently the treatment offered to patients with low-risk papillary thyroid microcarcinoma (PTMC). Here, the authors perform a multicentre online survey to a cohort of patients with PTMC showing that heightened regret may not be an experience of a minority of clinically low-risk PTMC patients and is primarily due to lower postoperative quality of life.
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