Imaging mass cytometry-based characterisation of fibroblast subsets and their cellular niches in systemic sclerosis

Using IMC, we demonstrated profound changes in composition and localisation of the majority of fibroblast subpopulations in SSc skin. These findings may provide a rationale for specific targeting of deregulated fibroblast subpopulations in SSc. Quantification of S1PR⁺-fibroblast and PI16⁺;FAP^--fibroblasts may offer potential for patient stratification according to severity of skin fibrosis.