免疫学
信号转导
疾病
气道
受体
白细胞介素4
医学
细胞
生物
细胞生物学
细胞因子
病理
内科学
遗传学
外科
作者
Ishita Choudhary,Richa Lamichhane,Dhruthi Singamsetty,Thao Vo,Frank Brombacher,Sonika Patial,Yogesh Saini
标识
DOI:10.1165/rcmb.2024-0208oc
摘要
IL-4 and IL-13 play a critical role in allergic asthma pathogenesis via their common receptor, i.e., IL4Rα. However, the cell-specific role of IL4Rα in mixed allergens (MA)-induced allergic asthma has remained unclear. Therefore, we aimed to identify the cell-specific contribution of IL4Rα signaling in the manifestation of various pathological outcomes in mice with allergic airway disease. We compared MA-induced pathological outcomes between hematopoietic progenitor cells (HPCs)- or non-HPCs-specific IL4Rα-deficient chimera, myeloid cell-specific IL4Rα-deficient (LysMcre
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