孤雌内酯
程序性细胞死亡
化学
配体(生物化学)
细胞凋亡
降级(电信)
细胞生物学
细胞
肿瘤细胞
癌症研究
生物化学
生物
受体
计算机科学
电信
作者
Xin Liu,Yi‐Yin Tai,Yu Bao Hou,Shen Cao,Jing Han,Ming Yue Li,Hong Xiang Zuo,Yue Xing,Xuejun Jin,Juan Ma
标识
DOI:10.1021/acs.jafc.4c04916
摘要
Parthenolide is a germacrane sesquiterpene lactone separated from the traditional medicinal plant feverfew. Previous studies have shown that parthenolide possesses many pharmacological activities, involving anti-inflammatory and anticancer activities. However, the antitumor mechanism of parthenolide has not been fully elucidated. Thus, we investigate the potential antitumor mechanisms of parthenolactone. We predicted through network pharmacology that parthenolide may target HIF-1α to interfere with the occurrence and development of cancer. We found that parthenolide inhibited PD-L1 protein synthesis through mTOR/p70S6
科研通智能强力驱动
Strongly Powered by AbleSci AI